Our Mission

Dr. Pan has been focusing on studying the mechanisms by which cancer evades immune responses in the tumor microenvironment (TME), more specifically the contribution of myeloid derived suppressor cells (MDSC) to tumor progression. His group is one of the first to demonstrate that MDSCs can act as a “Trojan Horse” in the delivery of oncolytic viruses or therapeutic agents used in direct tumor targeting, thereby preventing tumor metastases. His lab has also demonstrated the use of MDSC, as a cell-based tolerogenic therapy, to suppress unwanted immune responses, such as autoimmunity and graft-versus-host diseases (GVHD), while still retaining graft verse leukemia (GVL) function. More recently, Dr. Pan identified a potential role of myeloid inhibitory receptors in the maintenance of tumor-initiating cells (TIC) and radio/chemo-resistance of colon cancer.

Ping-Ying Pan, PhD

Professor of Oncology, Academic Institute
Full Member, Research Institute
Associate Director, Center for Immunotherapy Research
Houston Methodist

Ping-Ying Pan, PhD, is Associate Director of the Cancer Immunotherapy Research Center at Houston Methodist Research Institute. Prior to joining Houston Methodist, he was an Associate Professor in the Department of Oncological Sciences in the Icahn School of Medicine at Mount Sinai in New York. He obtained his Ph.D. from The University of Texas Health Science Center at San Antonio, Texas in 1996 and finished his postdoctoral training at Department of Medicine, Columbia University. In 2000, he became a senior research associate at Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine (currently Icahn School of Medicine at Mount Sinai, aka ISMMS), and rose to the rank of Associate Professor of the Department of Oncological Sciences, ISMMS in 2009. He has made significant contributions to the fields of cancer immunology and immunotherapy.